The 2 major effective components of Lingzhi are Triterpenoids and Polysaccharides.
The major component in Triterpenoids is Ganoderic Acids (more than 200 kinds have been isolated) while the most famous component in Polysaccharides is Beta-glucans.
Triterpenoid is very
unique because it is not found in other mushrooms. It can only be found in Lingzhi. So it can be used as a 'fingerprint' for Lingzhi. It has small molecule size (400-800). When it is digested, it enters into our blood vessels i.e. ganoderic acids can be detected in the blood of people who take Lingzhi. It can be
easily identified. It has
more functions than polysaccharides. As such, it has the most potential for new drugs development. Shuang Hor is currently the most qualified enterprise to undertake this development.
Liver Protection and Lingzhi
There is a research done by the cooperation of 3 universities in Taiwan, by scientists specialising in food science, medical science and sports science. The findings is published in the journal Molecules 2013, 18(2), 1741-1754. The article is called "
Ganoderma Tsugae Hepatoprotection against Exhaustive Exercise-Induced Liver Injury in Rats". The result shows that
Lingzhi can protect liver from injury induced by exhaustive exercise.
In this experiment, rats are made to run on treadmill. The rats are divided into control group and those administered with low, medium and high dose of Lingzhi before the run. The Lingzhi used is Shuang Hor's
Yung Kien Ganoderma. The high dose corresponds to 4 bottles of Yung Kien Ganoderma for human consumption. The reason why such a high dose is used is, in addition to testing for
Effectiveness of Lingzhi for liver protection, the scientists also want to test for
Safety level.
Whenever the rats stop running, they are given an electric shock to force them to continue running. They are given up to 5 electric shocks, until they are finally exhausted.
Results:
Control group - running time is 60 minutes.
Lingzhi group - running time is 80-90 minutes. The higher the dosage, the longer is the running time.
Rats fed with Lingzhi show no signs of liver damage after undergoing exhaustive exercise - the liver is protected by Lingzhi.
Athletes who train a lot or people who become overly exhausted will damage their liver and kidney. If they don't get sufficient rest, they can die. But
if they take Lingzhi, their liver will not be so easily damaged. For marathon runners, high dose of Lingzhi can help them get better results, and they will feel less tired.
Pharmaceutical Kinetic of Ganoderic Acid-A in Human Subjects (Double-blind) - How often should one take Lingzhi in a day?
Is there a difference if you consume Lingzhi every hour or only once a day?
This is an experiment published by the Chiang Mai University.
Human subjects are fed with Lingzhi every hour. The scientists analyse their blood every hour to find if there's any effective components such as Ganoderic Acid-A (GA-A) present in the blood.
The answer is Yes. When we take Lingzhi, our blood will have the effective components, including GA-A.
The findings show that if the subjects
take Lingzhi before meals, the effective components will be
absorbed much faster.
The GA-A reaches maximum concentration in plasma after 35 minutes. There's a higher ratio of GA-A after 35 mins in the blood. One hour later, the concentration drops to half. Because of that, if more concentration is needed, another dose needs to be supplied.
Hence according to this scientific data,
supplying another dose after 1 hour is reasonable.
It was found that after 12 hours, no more GA-A exists. There was no more effective components in the blood. Hence if needed, make sure that another dose is supplied within 12 hours duration.
Kidney Protection and Lingzhi
If your kidney no longer works, you will need dialysis. It is a blood-cleansing procedure that replaces the kidney function. Usually patients who are on dialysis will have to be on dialysis for the rest of their lives. However, it is found that
some people who take Lingzhi are able to return their kidney function back to normal.
Dr Chen conducted a test in his Bio-medical Institute in Taiwan using mice to find what is the real component that saves the kidney. The test is done using the FMT (Fluorescent Molecular Tomography) machine, a high resolution MRI for animals. Ganoderic acid is found to be the effective component. In the experiment, some chemical is used to induce kidney inflammation. The mice are then divided into control group and those fed with medium (300 mg/dL) and high dose (500 mg/dL) Lingzhi. 5 days later, the FMT images of their kidneys were taken. The deeper the color indicates the greater the inflammation. The images of mice that don't take Lingzhi show very deep color.
The images prove that mice fed with higher dose of Lingzhi show a lightening of the color i.e. a lower level of protein urea (abnormal amount of protein present in the urine) - 300 mg/dL for medium dose and 100 mg/dL for high dose.
In other words, mice that take
high dose Lingzhi can protect their kidney from inflammation and damage. This is the first proof that Ganoderic acid is able to protect the kidney from dialysis. So
for people who just start to undergo dialysis, it's possible to use high dose Lingzhi to prevent them from going through long-term dialysis.
Heart Protection and Lingzhi
Lingzhi is also very helpful to protect our heart. This is the first evidence that will prove it. Dr Mo was a uni-mate of Dr Chen and they graduated from National Cheng Kung University together. He then went to work in the University of Illinois before returning to Taiwan in 2005. He specialises in cardiology.
When Dr Mo was looking for some research he can do on what protects the heart, Dr Chen suggested Lingzhi. He was not interested. But about 4 years ago, when he came across a research paper on heart protection, he was reminded of the Lingzhi Dr Chen gave him. He used the sample and found that Lingzhi can indeed protect the heart. He wrote the Paper and submitted it to the Microbiological Research Foundation.
Test method:
Dr Mo used a myocardial injury model by challenging the mice with Isoproterenol i.e. injecting the mice with a chemical that causes their hearts to beat very quickly, which eventually damages the heart. After that, he administered the mice with Ganoderic Acid-A (GA-A), isolated from
Yung Kien Ganoderma. He found that GA-A is the effective component to protect our heart.
The images show that the hearts of the control group mice are purplish in color, i.e. there's presence of damaged tissues and some cells are dead. For the Lingzhi group - there is no purple area meaning no tissues are injured/dead. In other words,
GA-A is able to protect the heart cells.
His finding is published in Molecular Nutrition & Food Research 2013, 57(10), p.1892-1896. The article is titled "
The triterpenoids of Ganoderma Tsugae prevent stress-induced myocardial injury in mice".
GA-A is also found to be able to
prevent damage from Ractoamine, which is a feed additive to promote leanness in animals raised for their meat. It is banned in many countries (but still used in America at this point) due to its suspected health effects, including damage to our heart.
In a test, Ractoamine is used to induce damage in the heart cells of mice. When the mice that are administered with Ractoamine are also fed with Lingzhi, it was found that the cell damage level is lower. In other words, if you take a lot of American beef, you should consider taking Lingzhi as it can
protect heart cells from Ractoamine damage.
Conclusion
As you can see from above, there are many new findings on the capability of Lingzhi to protect our essential body organs, including our liver, kidney and heart.
The wisest way to take care of your Health is Prevention, not Treatment. So start taking Lingzhi when you're young and healthy. Don't wait until you're diagnosed with a disease. By that time, it will cost a lot, or worse, it may be too late.
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