One of the surest signs of ageing is when you need reading glasses. It usually starts when you're in your 40s, when you need to hold the menu further or squint while reading. This condition is called presbyopia - where as we age, the eye's crystalline lens harden, making it more difficult to adapt to near vision.

Quick Self-Check for Presbyopia

> Focus on the smallest text on a banknote.

> Look up at a distant object.

> Immediately look back at the small text on the banknote.

If your eyes cannot refocus within 1 second, it might be a sign of presbyopia.

Symptoms of presbyopia

• Eye fatigue when reading at close distance.
• Blurred vision when reading small print.
• Needing stronger light when reading or working at close distances.
• Having to extend your arm to see reading material clearly.
• Feeling nauseous, dizzy, or experiencing headaches.
• Unconsciously squinting often.

Kidney stones are small, hard deposits made of minerals inside the kidneys. Stones often go unnoticed until they move into the ureter and block urine from exiting, causing intense pain.

Many things can increase your risk for stones:

- Family history.

- Diabetes.

- Dietary habits.

- If urine lacks substances to prevent crystals from sticking together.

4 types of kidney stones

(i) Calcium stones

This type makes up about 70-80% of kidney stones. Calcium stones are usually made of calcium and oxalate (a substance produced by the liver). High doses of vitamins C and D, gastric surgery and some metabolic disorders can also increase the concentration of calcium or oxalate in the urine.

Calcium stones which are made of calcium phosphate are more common in people with metabolic conditions like renal tubular acidosis (main causes are diabetes and HBP). It may also be associated with medications to treat migraines (topiramate) or blood pressure (furosemide or triamterene).

(ii) Struvite stones

They form after a urinary tract infection (UTI), growing quickly and sometimes with few symptoms and little warning.

(iii) Uric acid stones

They form in people who lose too much fluid because of chronic diarrhoea or malabsorption, who eat a high-protein diet or who have gout.

(iv) Cystine stones

They form in people with a hereditary disorder called cystinuria, which cause the kidneys to excrete too much amino acid cystine.

How to reduce the risk or prevent a recurrence of kidney stones?

(i) Drink water throughout the day

People with a history of kidney stones should drink enough fluids to pass about 2.5 litres of urine everyday. This is the most effective therapy to prevent future kidney stones.

(ii) Dietary change

> Eat fewer oxalate-rich foods. Foods that are highest in oxalates include spinach, rhubarb, baked potatoes, lentils, navy beans, bran, grits and almonds.

> Eat less salt and animal protein.

> A diet lower in sodium and higher in potassium contained in many fruits and vegetables can reduce the risk of stone formation.

(iii) Use caution with calcium supplements

Be an educated consumer and choose wisely, as certain calcium supplements may be linked to an increased risk of kidney stones.

(iv) Take steps to reduce UTIs

Fewer infections can reduce the risk of developing struvite stones.

(Source: Stopping those kidney stones, Starhealth, 22 Oct 2023)

CEO Coffee is effective

I have heard of numerous testimonies from men reporting that after drinking 2-3 cups ofa CEO Coffee per day over a few weeks, they were able to urinate out the stones which have been causing them a lot of pain. CEO Coffee contains Lingzhi, which can soften stones in the kidney/pancreas and help them to be pushed out in the urine. When the stones are sufficiently softened, you won't feel pain when they are being passed out. 

Click on this link to find out what other benefits does CEO Coffee offer:

https://www.pingofhealth.com/2022/10/health-benefits-of-ceo-coffee-6.html

How to order CEO Coffee?

The older we get, the harder it is to lose weight. We need to put in more effort in order to lose the same amount of weight compared to when we were in our 20s. However, all is not lost. Here are 5 factors to consider for weight loss after you hit 50. I will also share with you what I do to maintain my weight while still enjoying the food I love.

1. Diet

> Caloric intake vs expenditure

If you consume more calories than your body uses, you'll gain weight. But it's not only that.. leptin and ghrelin are 2 hormones that control your appetite and fullness. If the ghrelin hormones don't function properly, you may always feel hungry and have increased appetite. On the other hand, if your leptin hormone signal is disrupted, you tend to eat a lot before feeling full.

Another hormone that plays an important effect on weight is the insulin hormone, which regulates glucose uptake from the bloodstream. Insulin resistance can make weight loss more challenging because it can lead to high blood sugar levels and increased fat storage.

What I do: I supplement with Lingzhi, because many research show it can keep my hormones balanced, so I don't always feel hungry, and I don't need to eat a lot before I am triggered to stop eating. Lingzhi has also been proven to successfully regulate my blood sugar level.

> Appropriate nutrients composition

Diets high in processed foods, sugars and unhealthy fats can lead to metabolic disturbances and weight gain. For some, when they reduce carbo intake, it helps with satiety and reduce insulin spikes.

What I do: I reduce my cravings for unhealthy snacks by supplementing with Yung Kien Pollen. I notice that when my body is sufficiently replenished with the appropriate vitamins and minerals, it naturally does not emit the "hunger signal".

2. Physical activity

The critical factor is regular, sustained activity, instead of intermittent bursts of exercise. Be mindful that you engage in enough physical activity to create a significant calorie deficit, and not over-estimate the amount of energy expended in doing certain types of exercise.

What I do: A brisk walk of 40 minutes every 2-3 days uphill and downhill does wonders for my heart health and leg muscles. It's free and I can do it any day, any time.

3. Metabolism

Our metabolic rate can be influenced by age, sex, body composition and genetic factors. Aim for a slow and steady weight loss to help minimise the effect of adaptive thermogenesis (which is when it's increasingly difficult to lose weight despite low calorie intake).

What I do: Lingzhi is my go-to as it regulates the functions of hormones and thyroid gland, which control metabolism.

4. Sleep and stress

Studies show that sleep deprivation can lead to increased calorie consumption, reduced energy expenditure and increased insulin resistance.

Chronic stress can lead to increased secretion of cortisol, a hormone that promotes fat storage, particularly in the belly area.

Behaviours such as eating in response to emotional cues rather than hunger or eating disorders eg. binge-eating, can sabotage weight-loss efforts. 

What I do: I am not tempted to eat unhealthy food and sweet snacks when faced with stressful situations. Meditation helps. Thinking calmly helps. Letting go of what I cannot control helps. Taking Lingzhi also helps, because of its calming properties. Many people have reported that Lingzhi helps them with their insomnia problem.

5. Medical conditions

Hypothyroidism patients have slower metabolism, making weight loss difficult. PCOS is associated with insulin resistance and obesity. Medications like antidepressants, antipsychotics and antiepileptics can lead to weight gain or hinder weight loss efforts.

What I do: Again, Lingzhi is well-known for its ability to regulate the thyroid hormones, as well as manage PCOS conditions. Lingzhi from Shuang Hor can penetrate the Blood-Brain-Barrier, making it a safe and effective choice for patients with epileptic and depression disorders.

Conclusion

Weight loss is a complex, multi-faceted process. That's why a one-size-fits-all approach is ineffective. Whatever strategies you adopt, they must be done gradually and the changes must be sustainable. This is certainly more successful in the long term than quick fixes.

Despite my age, I am indeed very blessed that I can still enjoy whatever food I fancy without worrying about the calories. Why? I believe that Lingzhi plays a huge role in helping me eat with moderation, get rid of toxins and modulate my hormones and metabolism.

What am I taking:

Lingzhi - Yung Kien I Ganoderma Powder

Pollen - Yung Kien Pollen Granular

(Source: Losing weight after 50, Starhealth 24 Dec 2023)

Please email me at askfuiping@gmail.com if you have questions.

How to Order Online?

Click on this link and follow the simple steps..

https://www.pingofhealth.com/p/order-online.html

Isn't it wonderful if you can lose weight without putting in much effort? This is a dream come true for those of us who are lazy or hate exercising. Well, it is possible to lose weight without exercising - provided you have the discipline to change your lifestyle.

Try some of the following tips..

1. Drink more water

When you wake up, drink 2 glasses of water to help activate your internal organs. Water offers many benefits such as helping to remove toxins from your body, regulate body temperature, lower blood pressure, carry nutrients and oxygen to body cells and maintain optimal kidney function. You can add fruit slices like oranges, mint or lemon for extra flavour and nutrients.

Tip: Drink a big glass of plain water 30 minutes before meals to help you feel fuller and reduce food intake.

2. Eat slowly and mindfully

Chewing longer helps suppress hunger and makes you full faster. The liquified food increases the amount of nutrients absorbed by the body and is easier on your digestive process.

Tip: Chew every mouthful at least 20 times before swallowing. 

3. More fibre and protein

Protein takes longer to digest and decreases the level of ghrelin (hunger-regulating hormone), making you feel fuller for a longer period. Fibre expands in your gut like a sponge, so it's a natural appetite suppressant. 

Tip: Drink a Protein-Fibre Shake about 20 minutes before meals, especially if you're planning to take deep-fried or oily food. The fibre forms a layer in your digestive system, and reduces the absorption of fats, sugar and salt, which not only control your weight but also prevent diabetes and constipation problem. Take a look at this video on how to make the shake:

http://www.pingofhealth.com/2020/08/nutritious-tasty-meals-anywhere-anytime.html

4. Cut down on sugar

If you want to lose weight, sugar should be the first thing to go. Be mindful of the "hidden" sugar eg. in your salad dressing, sauces, canned fruits, honey, creamer etc. By eliminating sugar, you lower your risk of heart disease dramatically as it reduces your risk of high blood pressure and diabetes.

Tip: If you like coffee, try CEO Coffee. This healthy coffee uses roasted beans, coconut oil instead of creamer and most importantly, contains Lingzhi. Not only does it taste delicious, it has the bonus of clearing blood vessels and preventing colon cancer. Click on this link for more details:

http://www.pingofhealth.com/2018/09/drinking-delicious-healthy-coffee.html

5. Manage stress levels

When your body is under pressure, it releases the hormone cortisol, which can increase cravings for energy-dense, comfort foods. High cortisol levels over time are also linked to abdominal fat gain.

Tip: Spend 5 minutes mid-morning and in the afternoon to do a few rounds of deep breathing.

6. Get proper sleep

Evidence shows that people who get too little sleep have a higher risk of weight gain than people who get 7 to 8 hours of sleep a night. Sleep deprivation changes your endocrine function and metabolism by affecting your production of hunger-regulating hormones ghrelin and leptin. This can make you feel hungrier than usual, increasing the likelihood of craving for unhealthy snacks.

Tip: Practise good sleep hygiene by sleeping at the same time every day and ensure the room temperature is comfortable.

(Source: Lose weight without exercise, Starhealth, 22 Oct 2023)

Long-term treatment of rheumatic illnesses like arthritis using cortisone (a type of glucocorticoids) can cause osteoporosis. Cortisone is a steroid hormone and reduces allergic-like reactions. According to the German Society for Rheumatology (DGRh), as a preventive measure, you should accompany it with calcium and vitamin D. 

What is a good source of calcium and vitamin D? 

Click on this link to find out what other types of vitamins and minerals are in a grain of pollen:

http://www.pingofhealth.com/2012/07/what-is-deal-with-bee-pollen.html

Experts say cortisone drugs are usually well tolerated when used for short periods. But if used for more than 3 months, there may be side effects like decrease in bone density, which lead to osteoporosis. In 30-40% of patients treated with cortisone over a period of 4.5 years, recent or older bone fractures could be detected, DGRh estimates. 

The problem is that many patients don't notice the small bone fractures precisely because of the medicine they are taking. Therefore, the bone problems are frequently overlooked and not treated. As a result, the skeleton becomes more fragile, thus promoting further fractures. In the first 3-6 months of glucocorticoid therapy, bone density decreases by up to 12%. 

After the end of treatment, the fracture risk declines again, as it is directly related to cortisone intake. Therefore, DGRh recommends taking as much cortisone as necessary, but as little as possible, in combination with preventive measures against possible bone loss.

In other words, a rheumatoid arthritis patient is faced with a serious challenge - they take cortisone to treat their arthritis. But long-term consumption may lead to brittle bones and osteoporosis.

What is a preferred alternative to cortisone?

Yung Kien Ganoderma. Because research found that Ganoderma possess immune-modulating and anti-allergic capabilities and can inhibit the development of chronic inflammation like rheumatoid arthritis. Click on this link for more info on scientific experiments showing that Ganoderma is proven to prevent auto-immune diseases:

http://www.pingofhealth.com/2019/01/exclusive-inflammation-causing-auto.html

(Source: Beware of your bones with cortisone, StarHealth, 2 Jan 2021)

How to order Yung Kien Pollen and Yung Kien Ganoderma?

Click on this link to register and then you can proceed with your order.

http://www.pingofhealth.com/p/order-online.html

Email me at askfuiping@gmail.com if you need help. I am an Authorised Distributor.

Evidence has closely linked the importance in gut microbes in the regulation of obesity. It was demonstrated that high-calcium diets appear to positively affect gut microbiota composition, favouring the growth of lactobacilli (good bacteria). Calcium supplementation modulates gut microbiota in a prebiotic manner, promoting a healthier metabolic profile and potentially prevent or treat obesity.

Functions of Calcium

• Maintain healthy bones and teeth.
• Muscle contraction.
• Nerve impulse transmission.
• Cellular metabolism.
• Normalise heart rhythm.
• Blood clotting.

Introducing Jia Hor Calcium Plus Tablets

These are the 3 key compositions of Jia Hor Calcium Plus Tablets:

1) Dairy calcium

- Contains the best-known natural calcium source that is exclusively extracted from dairy's milk.

2) Vitamin D3

- Enriched with ample amount of vitamin D3 which aids in calcium absorption.

3) Casein phosphopeptide (CPP)

- Approved by the Health Ministry of Japan and subsequently listed as an ingredient for "specific healthcare food supplements". CPP is derived from milk protein casein and functions to prevent calcium deposition in the digestive system.

(Source: SH Magazine July 2023)

Micro means small and Biome means a community of living beings. Together, the word Microbiome means a community of microorganisms that live in all regions of our body. This post focuses on the community of microbiome that resides in our guts, also known as Probiotics.

These probiotics which inhabit our digestive tract are commonly called the "good" bacteria. They play a significant role in digestion, immune function, brain health and the ageing process.

Health benefits of probiotics

1. Gut health

> Probiotics optimises gut function by restoring the natural balance of gut bacteria. This is especially important because when we fall sick, the bad microorganisms usually outnumber the good bacteria. 

> Prevents and treats diarrhoea eg. from food poisoning or antibiotics.

> Reduces symptoms of certain digestive disorders eg. IBS.

2. Immune system

> Protect against colds and flu (as 70-80% of our immune system are present in the gut).

> Prevent UTIs.

> Reduce severity of certain allergies and eczema.

3. Mind and brain

We usually hear the term Physical Health ~ we should do more exercise and be more physically active. Nowadays, the word Mental Health is the centre of attention. It comprises of 3 aspects: Psychological, Emotional and Social wellbeing. It affects how we think, feel and act. It also determines how we handle stress, relate to others and make healthy choices.

The National Health and Morbidity Survey reported some pretty scary statistics - the number of mental health cases among Malaysians above 16 years old has increased from 10.7% (1996), to 11.2% (2006), and 29.2% (2015). This means approximately 1 in 3 Malaysians had mental health problems in 2015.

Have you heard of the phrase "gut-wrenching experience" or have you ever suffer from the feeling of "butterflies in your stomach"? This is because our gut and brain are connected. The Gut-Brain Axis is a 2-way communication system between our gut (digestive system) and brain (central nervous system). It plays a significant role in our emotions and stress response. The enteric nervous system that regulates our gut is often called the body's Second Brain. It's like a mini-brain that lives in the intestines and helps manage digestion. This Second Brain also sends messages to the big brain; that's why the Gut-Brain Axis is so important. In other words, probiotics play a part in our mental health. 

Studies show that taking probiotics can:

> Improve your mood and reduce stress.

> Help with certain mental disorders like depression or anxiety.

4. Other health benefits

> Helps in weight loss as probiotics can help utilise the energy in our food.

> Keeps your heart healthy by maintaining healthier cholesterol levels.

> Promote oral health (reduction of gum disease and prevent caries).

Probiotics v. Prebiotics

Probiotics are food or supplement that contain live microorganisms.

Prebiotics are non digestible food components that selectively stimulate the growth or activity of probiotics.

In order to reach our intestines alive, the probiotics must be able to endure the harsh conditions in the stomach such as strong acid and digestive enzymes, which kill many microorganisms.  

Manufacturers overcome this problem by using special production processes and formulation to enhance the tolerance of probiotics to acidic conditions. Some bacterial strains have a naturally inbuilt level of tolerance to acidic conditions. In other words, it all depends on the type and manufacturing process of the probiotic you take.

Key traits of Lactoberry probiotics

The probiotics used in Lactoberry is multicoated with Oligosaccharides (food supply of probiotics) thus giving the probiotics more energy and enhanced potency. This coating increases the probiotic's tolerance against gastric acid and bile salt. Further, the probiotics also can stay in the GI tract for a longer time.

6 Ingredients & Benefits of Lactoberry

1. Bifidobacterium lactis

> Improves digestive conditions in the body eg. lactose intolerance and gluten toxicity as well as improves constipation by reducing gut-transit time.

> Assists digestion and utilisation of nutrients eg. sugar, fibre and macronutrients. It's also partially responsible for the absorption and utilisation of certain vitamins and minerals.

> As about 70% of probiotics are present in our gut, they have an immuno-modulating effects, especially for upper respiratory tract infections eg. common flu and cold.

2. Bifidobacterium longum

> Alleviates GI disorders eg. constipation and antibiotic associated diarrhoea.

> Immuno-modulation eg. improves symptoms of allergy and infections.

> Improvement and homeostasis of intestinal microenvironment. Studies have shown that with decreased micro-biodiversity, we are more prone to have diseases especially metabolic disorders like diabetes.

3. Isomalt

> Sugar substitute. Hence, Lactoberry can be ingested by diabetics.

> Prebiotics, therefore it's a food source for probiotics.

> Stimulates peristalsis, softens stools and alleviates constipation.

4. Berries

> Cranberry powder prevents UTIs due to it containing an abundance of phytonutrients A-type proanthocyanidins or condensed tannins. It prevents the E.Coli bacteria from attaching to the lining of the bladder and urinary tract.

> Raspberry powder, which has one of the richest sources of fibre amongst fruits and tannin content. It prevents constipation by increasing the bulk and letting the stools come out more easily, as well as benefits blood sugar control by improving insulin resistance.

> Blueberry powder is high in antioxidant flavonoids such as anthocyanin, which neutralises free radicals and enhances metabolic waste excretion.

Who needs it?

> Children, teenagers, adults and elderlies.

> Pregnant ladies.

> Patients after medical treatments.

Recommended consumption

> 1-2 sachets for daily maintenance before or after meals. To ensure the benefits of probiotics are reaped, it's important to take Lactoberry on a daily and on-going basis.

> Under special condition such as food poisoning or constipation, increase dosage as needed.

(Source: SH seminar, 22/7/2023)

How to Order? 

A box of 30 sachets of Lactoberry probiotics costs RM77 for Malaysian members.

Malaysians enjoy relatively cheap public healthcare and pride ourselves on globally high-ranked health services. Thus, many of us only look for help when we are ill. But isn't it better to prevent yourself from becoming sick in the first place, rather than seeking treatment only when feeling unwell?

Nutrition plays a very important role in maintaining health and preventing diseases. We all know as we are constantly bombarded with many tips on how to stay healthy. The question is how often do you remember all these Tips?

• Practice BMV (balance, moderation, variety) when having meals.
• Consume more vegetables and fruits. Choose whole grains instead of refined grains. Choose fish and lean meat instead of processed meat.
• Steam, grill and stew instead of deep-fry when cooking at home.
• Limit salt, sugar, fat and oil when cooking. Substitute with herbs and spices as seasoning.
• Drink sufficient water daily. Reduce intake of sugar-sweetened beverages.
• Be mindful of salt, sugar and fat content in packaged foods.
• Look for eateries with healthy options near your workplace.
• Do not skip meals as this can make you hungrier during the next meal, leading to overeating.
• When eating snacks, consume in moderation and choose healthier snacks like bananas, raisins, nuts etc.
• Be a good role model to your children by practising healthy eating yourself.
• For school, prepare healthier home-cooked/packed lunchboxes for your children.
• Beware of fed diets and unscrupulous advertising. 

Doing an annual blood test is an important way to keep track of your overall physical well-being. However, you may want to do it more often if you:

How to purchase?

Click on this link to register and then you can proceed with your order.

http://www.pingofhealth.com/p/order-online.html

Email me at askfuiping@gmail.com if you need help. I am an Authorised Distributor.

Click here to refer to Shuang Hor company website for Product Description and Price. Have an awesome day!

Osteoporosis is a disease that causes bones to become weak and brittle. It occurs when the creation of new bone can't keep up with the loss of old bone. The risk of osteoporosis is higher in people who are frail, underweight, small in built and post-menopausal women. 

Many people think losing bone density and sustaining fractures are simply a natural part of the ageing process, but this is a Myth. Statistics show that 1 in 4 people who fall and fracture the hip will not survive beyond 12 months - which is worse than some cancer diagnoses! Unfortunately, despite its devastating effects, osteoporosis remains under-diagnosed and under-treated.

Factors affecting bone health include: 

• Nutrition - nutritional malabsorption, eating disorders.
• Age - don't take solid food, don't chew well.
• Hormones - post-menopausal.
• Lifestyle - physical inactivity.
• Pre-existing diseases - diabetes, thyroid disorders, rheumatoid arthritis.
• Medications - steroids.

In osteoporosis, you can fracture the spine without having to fall. So if you bend over to pick up a pot of flowers or your grandchild, you may get back pain. This could be a sign of a fractured spine. It is essential to prevent even the first fracture, because once you have had one fracture, you're likely to experience another. There are medicines that can be tailored to suit all sorts of patients. However, for me, I won't take medicines to prevent osteoporosis. 

I would choose Vitaking collagen.

Why? Because it is safe and doesn't have side effects. I have been drinking it consistently for over 15 years for maintenance and protection. However, when I sprained my ankle or twisted my shoulder, I increased the dose to enjoy the curative benefits.

Click on this link for 10 commonly asked questions on Vitaking such as whether it's effective for bone spurs, numbness in the limbs, arthritis, pregnant ladies etc:

http://www.pingofhealth.com/2019/03/your-questions-on-vitaking-collagen.html

(Source: Holey bones, StarHealth, 12/2/2023)

How to purchase?

Click on this link to register and then you can proceed with your order of Vitaking collagen.

http://www.pingofhealth.com/p/order-online.html

Email me at askfuiping@gmail.com if you need help. I am an Authorised Distributor.

Click here to refer to Shuang Hor company website for Product Description and Price. Have an awesome day!

From the ribbon-cutting ceremony and lion dance, to leadership sharing direction, science-based nutrition talks, and conversations unfolding naturally over coffee, it was inspiring to witness how business, people, and purpose came together in one space.

Click on this link to view the 1-minute video, which I posted in my Facebook Page:

CEO Coffee Lounge Grand Opening

Moments like this remind me why I continue this journey - not just for products, but for the conversations, learning, and community behind them.

If you’re curious about what Shuang Hor stands for today, or how Ping of Health fits into this ecosystem, feel free to reach out. I’m always happy to share my own experience.

Email: askfuiping@gmail.com

#PingOfHealth #ShuangHor #CEOCoffeeLounge #Contest

In November 2025, Ms Yu-Chi Cheng shared a presentation on the range of Ganoderma products offered by Shuang Hor and addressed 5 frequently asked questions. Below are her credentials:

These are the links:

Part 3 - https://pingofhealthexclusive.blogspot.com/2025/12/range-of-ganoderma-lingzhi-products.html

Part 4 - https://pingofhealthexclusive.blogspot.com/2025/12/which-lingzhi-product-to-choose-and.html

If you are already authorised, just click on the links above.

However, if you are not already a consumer of Shuang Hor products, but are interested to find out more, drop me an email at askfuiping@gmail.com. I am happy to answer your questions so you can decide whether you want to give Shuang Hor Ganoderma a try. 

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The Blood Brain Barrier functions to keep harmful organisms and substances out of our brain. But it's a double-edged sword as it can also prevent useful drugs from crossing in. Let's find out more..

Our brain is one of the most complex organs in our body. It weighs about 2% of our total body weight, but utilises about 20% of our energy. There are more than 100 billion brain cells which communicate by electrical impulses known as synapses.

The brain is shielded from an influx of harmful substances by a layer of endothelial cells called Blood-Brain Barrier (BBB). It provides a natural protective function to impede the entry of harmful substances into the central nervous system (CNS). The BBB regulates:

• delivery of nutrients into the brain.
• removal of unwanted toxins.
• recruitment of leukocytes (WBC) to maintain normal brain homeostasis (balance).

- Nanoparticles bear naturally-occurring components to cross the BBB. They can evade recognition by the immune system and thus escape destruction in the event of inflammatory response.

Nanoparticles have been engineered to effectively transport drugs across the BBB by targeting receptors involved in endocytosis (a process by which a cell brings substances into itself).  

Many studies have been carried out, such as:

(a) An animal study using rats, described the delivery of an anti-epileptic peptide, galanin, that is capable of inhibiting glutamate release in the hippocampus (thereby reducing the onset of seizures).

(b) A study targets the alpha-synuclein protein, which plays a role in Parkinson.

(c) An animal study assessed the inhibition of alpha-synuclein fibrillation and protection from the progressive loss of dopaminergic neutrons, in relation to Parkinson.

(d) In another study, researches have proven that alpha-synuclein can be prevented from activating in microglial cells via scavenger receptor CD36-binding nanoparticles.

(e) In an animal study of Parkinson, lipid nano carriers loaded with GDNF (glial cell derived neurotrophic factor) plasmids were combined with micro bubbles for MRI-guided focused ultrasound mediated effects that led to a reduction in nerve cell death and helped alleviate behavioural changes due to the disease.

The nose-to-brain route of administration could be a way to improve the delivery of drug-loaded particles to specific regions of the brain. Delivery via this route bypasses the BBB and enables direct delivery to the brain. The complication with this strategy is that:

(i) It requires the nanoparticles to have augmented properties, such as protecting the molecules within them from being destroyed or damaged in the nasal cavity; and 

(ii) Nanoparticles need to get through the nose's mucosal barrier.

The clinical translation of nanoparticles (ie. nanoparticles approved for brain targeting and treatment) is difficult and demanding as it requires substantial time and effort.

(Source: Infiltrating the BBB, StarHealth 15/1/2023)

Yung Kien C Ganoderma

The good news is Shuang Hor has successfully developed a product called Yung Kien C Ganoderma (YKC), which is effective for brain diseases. This is achievable because the ganoderic acid component in YKC has very small molecular structure and thus can pass through the BBB into the brain tissues. As such, YKC has a good effect on brain diseases such as seizures, epilepsy, Alzheimer and Parkinson. It is a breakthrough for Shuang Hor.

In an experiment, mice whose brain have been induced with Alzheimer are fed with YKC. The result shows YKC can improve the diseases that cause degeneration of brain neurons. 

How to purchase?

Click on this link to register and then you can proceed with your order of YKC 

http://www.pingofhealth.com/p/order-online.html

Email me at askfuiping@gmail.com if you need help. I am an Authorised Distributor.

Click here to refer to Shuang Hor company website for Product Description and Price. Wish you a good day!